作者
GM Buck Louis, JM Weiner, BW Whitcomb, R Sperrazza, EF Schisterman, DT Lobdell, K Crickard, H Greizerstein, PJ Kostyniak
发表日期
2005/1/1
期刊
Human Reproduction
卷号
20
期号
1
页码范围
279-285
出版商
Oxford University Press
简介
BACKGROUND: Hormonally active environmental agents have recently been associated with the development of endometriosis. METHODS: We undertook a study to assess the relationship between endometriosis, an estrogen-dependent gynaecological disease, and 62 individual polychlorinated biphenyl (PCBs) congeners. We enrolled 84 eligible women aged 18–40 years undergoing laparoscopy for study, which included an interview and blood specimen (n=79; 94%). Thirty-two women had visually confirmed endometriosis at laparoscopy while 52 did not. Blood specimens were run in batches of 14 including four quality control samples for toxicological analysis. Each PCB congener was adjusted for recovery; batch-specific reagent blanks were subtracted. All PCB concentrations were log transformed and expressed in ng/g serum first as a sum and then as tertiles by purported estrogenic or anti-estrogenic …
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