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Beach-cast seaweeds are unexplored feedstock with plentiful biomass in some localities that could be exploited as important sources of natural products. This study evaluated the potential of beach-cast seaweed extracts to inhibit the reverse transcriptase enzyme of the HIV-1. In general, the aqueous extracts showed better biotechnological potential as an antiviral agent than methanolic extracts with lower values of IC₅₀. However, both extracts from Alsidium seaforthii, Osmundaria obtusiloba, Dictyopteris jolyana, and Zonaria tournefortii were highly promising, reaching inhibition above 90%, as well the aqueous extract of Spyridia clavata. Macroalgae are characterized by high levels of sulphated polysaccharides, such as the carrageenan and agar sulphated galactans in red algae, fucans and fucoidans in brown algae, and heterofucans in green algae, which have been related to antiviral biological activity …