查看文章

As shown in large epidemiological studies traffic noise promotes the development of cardiometabolic diseases. Therefore, there is a need to effectively mitigate the noise-associated adverse health side effects. Here, we examined in an aircraft noise exposure murine model the potential protective role of an activation of the adenosine monophosphate-activated protein kinase (α1AMPK) and the NRF2/heme oxygenase-1 pathway. Wild-type (B6. Cg-Tg (Cdh5-cre) 7Mlia/J) mice were exposed to aircraft noise (maximum sound pressure level of 85 dB (A), average sound pressure level of 72 dB (A)) for the last 4d. Activation of α1AMPK was performed using 3 established protocols, including 5-aminoimidazole-4-carboxamide riboside (AICAR) application, voluntary exercise, or intermittent fasting. Activation of NRF2/heme oxygenase-1 pathway was performed using either hemin or dimethyl fumarate (DMF) administration …