作者
Kaveh Baghaei, Leila Shokrzadeh, Fereshteh Jafari, Hossein Dabiri, Yoshio Yamaoka, Mehdi Bolfion, Homayon Zojaji, MM Aslani, Mohammad Reza Zali
发表日期
2009/9/1
期刊
Digestive and Liver Disease
卷号
41
期号
9
页码范围
634-638
出版商
WB Saunders
简介
BACKGROUND
The cag pathogenicity island (PAI), which can divide into two parts: cagI and cagII, is the most well-known virulence factor of Helicobacter pylori.
AIMS
We investigated the association between genetic variations within the cag PAI (cagA and cagE in the cagI and cagT in the cagII) and clinical outcomes in Iranian population.
SUBJECTS
A total of 231 patients including 182 patients with gastritis, 41 with peptic ulcer and 8 with gastric cancer.
METHODS
The presences of the cagA, cagE and cagT genes were measured by polymerase chain reaction and the results were compared with clinical outcomes and gastric histology.
RESULTS
The cagA, cagE and cagT genes were found in 154 (66.7%), 90 (39.0%) and 70 (30.3%) of clinical isolates. At least 144 (62.3%) strains possessed partially deleted cag PAI (e.g., 69 [29.9%] strains were cagA-positive, but cagE and cagT-negative).
CONCLUSION
The …
学术搜索中的文章
K Baghaei, L Shokrzadeh, F Jafari, H Dabiri… - Digestive and Liver Disease, 2009