查看文章

Abstract Angiotensin-(1–7) is a bioactive component of the renin–angiotensin system that is formed endogenously and induces nitric oxide release in several tissues. The l-arginine/NO/cyclic GMP pathway and ATP-sensitive K+ channels have been proposed as the mechanism of action for the peripheral antinociception of several groups of drug and endogenous substances, including opioids, non-steroidal analgesics, acetylcholine and others. The aim of the present study was to investigate the involvement of the l-arginine/NO/cGMP and K ATP+ pathway on antinociception induced by angiotensin-(1–7). Paw pressure in rats was used to induce hyperalgesia via an intraplantar injection of prostaglandin E 2 (2 μg/paw). Ang-(1–7)(2, 3 and 4 μg/paw) elicited a local peripheral antinociceptive effect that was antagonized by the nonselective NO synthase (NOS) inhibitor l-NOarg and the selective neuronal NOS (nNOS …