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Introduction Reducing sugar-sweetened beverage consumption through taxation is a promising public health response to the obesity epidemic in the US This study quantifies the expected health and economic benefits of a national sugar-sweetened beverage excise tax of $0.01/ounce over 10 years. Methods A cohort model was used to simulate the impact of the tax on BMI. Assuming ongoing implementation and effect maintenance, quality-adjusted life-years gained and disability-adjusted life-years and healthcare costs averted were estimated over the 2015–2025 period for the 2015 US population. Costs and health gains were discounted at 3% annually. Data were analyzed in 2014. Results Implementing the tax nationally would cost $51 million in the first year. The tax would reduce sugar-sweetened beverage consumption by 20% and mean BMI by 0.16 (95% uncertainty interval [UI]= 0.06, 0.37) units among …