作者
Gordan M Vujanić, Manfred Gessler, Ariadne HAG Ooms, Paola Collini, Aurore Coulomb-l’Hermine, Ellen D’Hooghe, Ronald R de Krijger, Daniela Perotti, Kathy Pritchard-Jones, Christian Vokuhl, Marry M van den Heuvel-Eibrink, Norbert Graf, International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG)
发表日期
2018/11
来源
Nature Reviews Urology
卷号
15
期号
11
页码范围
693-701
出版商
Nature Publishing Group UK
简介
On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP–RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy. The UMBRELLA protocol aims to validate new prognostic factors, such as blastemal tumour volume and molecular markers, to further improve outcome. To achieve this aim, large, international, high-quality databases are needed, which dictate optimization and international …
学术搜索中的文章
GM Vujanić, M Gessler, AHAG Ooms, P Collini… - Nature Reviews Urology, 2018