作者
Marry M Van Den Heuvel-eibrink, Janna A Hol, Kathy Pritchard-Jones, Harm Van Tinteren, Rhoikos Furtwängler, Arnauld C Verschuur, Gordan M Vujanic, Ivo Leuschner, Jesper Brok, Christian Rübe, Anne M Smets, Geert O Janssens, Jan Godzinski, Gema L Ramírez-Villar, Beatriz De Camargo, Heidi Segers, Paola Collini, Manfred Gessler, Christophe Bergeron, Filippo Spreafico, Norbert Graf
发表日期
2017/12
来源
Nature Reviews Urology
卷号
14
期号
12
页码范围
743-752
出版商
Nature Publishing Group
简介
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP–RTSG. The …
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MM Van Den Heuvel-eibrink, JA Hol, K Pritchard-Jones… - Nature Reviews Urology, 2017