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Background: Craniopharyngiomas are tumorous embryogenic malformations. As the survival rate after craniopharyngioma is high (92%), prognosis and quality of life (QoL) in survivors mainly depend on adverse late effects such as obesity. Patients and methods: We analyzed 214 children and adolescents with craniopharyngioma. The records of 185 patients (86%) were available for retrospective analysis of weight profiles and risk factors for obesity. Quality of life (QoL) was measured in 145 patients by the Fertigkeitenskala Münster/Heidelberg score (FMH) and in 77 patients by PEDQOL questionnaire. Results: Eighty-two of 185 patients (44%) developed severe obesity (body mass index [BMI]> 3 SD). Obese patients were compared with 79 patients (43%) who kept normal weight (BMI< 2 SD). No differences between obese and normal weight patients were found in terms of gender distribution, age at diagnosis and …