作者
Brian D Nicholson, Jason Oke, Pradeep S Virdee, Dean A Harris, Catherine O'Doherty, John ES Park, Zaed Hamady, Vinay Sehgal, Andrew Millar, Louise Medley, Sharon Tonner, Monika Vargova, Lazarina Engonidou, Kaveh Riahi, Ying Luan, Sara Hiom, Harpal Kumar, Harit Nandani, Kathryn N Kurtzman, Ly-Mee Yu, Clare Freestone, Sarah Pearson, FD Richard Hobbs, Rafael Perera, Mark R Middleton
发表日期
2023/7/1
期刊
The Lancet Oncology
卷号
24
期号
7
页码范围
733-743
出版商
Elsevier
简介
Background
Analysis of circulating tumour DNA could stratify cancer risk in symptomatic patients. We aimed to evaluate the performance of a methylation-based multicancer early detection (MCED) diagnostic test in symptomatic patients referred from primary care.
Methods
We did a multicentre, prospective, observational study at National Health Service (NHS) hospital sites in England and Wales. Participants aged 18 or older referred with non-specific symptoms or symptoms potentially due to gynaecological, lung, or upper or lower gastrointestinal cancers were included and gave a blood sample when they attended for urgent investigation. Participants were excluded if they had a history of or had received treatment for an invasive or haematological malignancy diagnosed within the preceding 3 years, were taking cytotoxic or demethylating agents that might interfere with the test, or had participated in another study of …
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BD Nicholson, J Oke, PS Virdee, DA Harris… - The Lancet Oncology, 2023