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Nanotechnology has tremendous potential in the field of dentistry to provide a comprehensive oral health care with advanced nanomaterials, clinical devices, and advanced diagnostic tools. The impact of nanotechnology in oral health has enhanced the quality of dental care by manifolds. Nanomaterials in dental products can improve quality and have superior properties due to numerous active functional groups in nanomaterials. The nanodentistry is thus opening up new horizons for immense possibilities in dental research, but one should keep eyes on safety, efficacy, and implementation of nanotechnology. This chapter is a sincere effort to extend the horizons of nanomaterials and their windfall for dentistry.