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The purpose of this study is the prevention of Candida colonies on PMMA Denture Base by altering the surface and incorporations of Nanoparticles.

The Pub Med/Medline was searched to identify 100 relevant studies published from 2011 to 2020. The search strategy employed the following keywords related to “use of Nanoparticles in dentistry”, “Antimicrobial agents and PMMA”, “Candidiasis and nanomaterials”, “Prevention of oral Candidiasis”, “Incorporation of antimicrobial agents in acrylic dentures,” “nanoparticles as therapeutic agents for denture stomatitis”, “Nanodentistry” or “Nanotechnology” or “Nanocomposite” or “Nanodrugs” or “Nanomaterials”.

Most of the studies shows that modified PMMA denture base resin containing different antimicrobial coatings and incorporation of metal oxides Nanoparticles and other nanomaterials showed antifungal activity in vitro …