作者
JK Bosdou, CA Venetis, EM Kolibianakis, KA Toulis, DG Goulis, L Zepiridis, BC Tarlatzis
发表日期
2012/3/1
来源
Human reproduction update
卷号
18
期号
2
页码范围
127-145
出版商
Oxford University Press
简介
BACKGROUND
The aim of this meta-analysis was to evaluate the role of androgens or androgen-modulating agents on the probability of pregnancy achievement in poor responders undergoing IVF.
METHODS
Medline, EMBASE, CENTRAL, Scopus and Web of Science databases were searched for the identification of randomized controlled trials evaluating the administration of testosterone, dehydroepiandrosterone (DHEA), aromatase inhibitors, recombinant luteinizing hormone (rLH) and recombinant human chorionic gonadotrophin (rhCG) before or during ovarian stimulation of poor responders.
RESULTS
In two trials involving 163 patients, pretreatment with transdermal testosterone was associated with an increase in clinical pregnancy [risk difference (RD): +15%, 95% confidence interval (CI): +3 to +26%] and live birth rates (RD: +11%, 95% CI: +0.3 …
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JK Bosdou, CA Venetis, EM Kolibianakis, KA Toulis… - Human reproduction update, 2012