作者
EM Kolibianakis, CA Venetis, K Diedrich, BC Tarlatzis, G Griesinger
发表日期
2009/11/1
来源
Human reproduction update
卷号
15
期号
6
页码范围
613-622
出版商
Oxford University Press
简介
BACKGROUND
Whether the addition of growth hormone (GH) can improve the probability of pregnancy in poor responders undergoing ovarian stimulation for in-vitro fertilization (IVF) has been examined to date by several underpowered studies, which have not provided solid conclusions.
METHODS
A computerized literature search in MEDLINE, EMBASE, CENTRAL and randomized controlled trial (RCT) registries was performed independently by two reviewers, aiming to identify RCTs that evaluated the following research question: does GH addition increase the probability of pregnancy in poor responders undergoing ovarian stimulation with gonadotrophin releasing hormone (GnRH) analogues and gonadotrophins for IVF?
RESULTS
Six relevant RCTs were identified, including a total of 169 patients. GH addition significantly increased clinical …
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EM Kolibianakis, CA Venetis, K Diedrich, BC Tarlatzis… - Human reproduction update, 2009