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Biomedical patches are playing an indispensable role in wound infection management. Current efforts have focused on designing smart patches with both treating and sensing abilities to recognize wound infections and kill bacteria efficiently. Here, we present intelligent colorimetric microneedle patches (MNs) integrated with Fe ion-gallic acid coordination polymer nanodots (FNDs) for on-demand treatment and real-time report of infected wounds. Such FNDs are fabricated by coordination reactions among polyvinylpyrrolidone (PVP), gallic acid, and Fe ion, and are loaded inside the MNs using a template replication method (FNDs-MNs). Benefitting from the pH-dependent peroxidase mimic activity of the FNDs, the integrated MNs can catalyze H₂O₂ to generate much more radical dotOH at the acidic condition for bacteria killing. Besides, these FNDs-MNs also possess pH and H₂O₂ dependent color changes, and …