作者
Mariana Laundry de Mesquita, José Elias de Paula, Cláudia Pessoa, Manoel Odorico de Moraes, Letícia Veras Costa-Lotufo, Raphael Grougnet, Sylvie Michel, François Tillequin, Laila Salmen Espindola
发表日期
2009/6/25
期刊
Journal of ethnopharmacology
卷号
123
期号
3
页码范围
439-445
出版商
Elsevier
简介
The search for new anti-cancer drugs is one of the most prominent research areas of natural products. Numerous active compounds isolated from Brazilian Cerrado plant species have been studied with promising results.
AIM OF THE STUDY
To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture.
MATERIAL AND METHOD
Maceration of 50 plant species resulted in 412 hexane, dichloromethane, ethanol and hydroalcohol extracts. The cytotoxicity of the extracts was tested against human colon carcinoma (HCT-8), melanoma (MDA-MB-435), and brain (SF-295) tumor cell lines, using the thiazolyl blue test (MTT) assay. Bioassay-guided fractionation was performed for one active extract.
RESULTS AND CONCLUSIONS
Twenty-eight of the 412 tested extracts demonstrated a substantial antiproliferative …
引用总数
学术搜索中的文章
ML de Mesquita, JE de Paula, C Pessoa… - Journal of ethnopharmacology, 2009
PJE Mesquite de MC, C Pessoa - J Ethnopharmacol, 2009
