作者
Na‐Young Song, Young‐Joon Surh
发表日期
2012/10
来源
Annals of the New York Academy of Sciences
卷号
1271
期号
1
页码范围
10-19
出版商
Blackwell Publishing Inc
简介
Silent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins. Notably, cumulative evidence supports the notion that SIRT1 has a Janus‐faced role in tumorigenesis. SIRT1 contributes to anti‐inflammation, genomic stability, and cancer cell death, and hence it has tumor‐suppressor properties. On the other hand, SIRT1 can stimulate oncogenic signaling pathways and can create a tumor microenvironment favorable to growth and survival of cancer cells. Such dual functions of SIRT1 may be determined, at least in part, by its subcellular localization. Interestingly, SIRT1 displays differential localization in normal cells and cancer cells, which in turn may affect the substrate specificity for its deacetylase activity.
学术搜索中的文章
NY Song, YJ Surh - Annals of the New York Academy of Sciences, 2012