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15‐Deoxy‐Δ^12,14‐prostaglandin J₂ (15d‐PGJ₂), a representative J‐series cyclopentenone prostaglandin, exerts cytoprotective effects that are mainly mediated by Nrf2. Nrf2 is a major transcription factor involved in the transactivation of genes encoding many phase 2 detoxifying and antioxidant enzymes via interaction with the antioxidant response element (ARE). Recently it has been reported that expression of phase 3 efflux transporters, such as multidrug resistance‐associated proteins (MRPs), is also regulated by Nrf2. It is well known that cancer cells overexpressing MRPs are more resistant to anticancer drugs. In the present study we have found that 15d‐PGJ₂ induces the expression of MRP1, one of the phase 3 efflux transporters, in human breast cancer cells (MCF‐7). In addition, treatment of MCF‐7 cells with 15d‐PGJ₂ resulted in nuclear translocation and DNA binding of Nrf2. In contrast to 15d‐PGJ₂, 9 …