作者
B Daan Westenbrink, Erik Lipšic, Peter van der Meer, Pim van der Harst, Hisko Oeseburg, Gideon J Du Marchie Sarvaas, Johan Koster, Adriaan A Voors, Dirk J van Veldhuisen, Wiek H van Gilst, Regien G Schoemaker
发表日期
2007/8/1
期刊
European heart journal
卷号
28
期号
16
页码范围
2018-2027
出版商
Oxford University Press
简介
Aims
Erythropoietin (EPO) improves cardiac function and induces neovascularization in chronic heart failure (CHF), although the exact mechanism has not been elucidated. We studied the effects of EPO on homing and incorporation of endothelial progenitor cells (EPC) into the myocardial microvasculature and myocardial expression of angiogenic factors.
Methods and results
CHF was induced in rats by coronary artery ligation resulting in myocardial infarction (MI) after bone marrow had been replaced by human placental alkaline phosphatase (hPAP) transgenic cells. We studied the effects of darbepoetin alfa treatment (EPO, 40 µg/kg, every 3 weeks, starting 3 weeks after MI) on longitudinal changes in left ventricular (LV) function, circulating EPC, myocardial histology, and expression of vascular endothelial growth factor (VEGF) determined 9 weeks after MI. EPO prevented …
引用总数
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BD Westenbrink, E Lipšic, P van der Meer… - European heart journal, 2007