作者
Kristine S Wong, Fei Dong, Milhan Telatar, Jochen H Lorch, Erik K Alexander, Ellen Marqusee, Nancy L Cho, Matthew A Nehs, Gerard M Doherty, Michelle Afkhami, Justine A Barletta
发表日期
2021/6/1
期刊
Thyroid
卷号
31
期号
6
页码范围
933-940
出版商
Mary Ann Liebert, Inc., publishers
简介
Background: Similar to poorly differentiated thyroid carcinoma (PDTC), papillary thyroid carcinoma with high-grade features (PTC HGF) demonstrates increased mitotic activity and/or necrosis; however, PTC HGF is excluded from the World Health Organization (WHO) definition of PDTC based on maintained nuclear features of PTC.
Methods: Consecutive tumors that met criteria for PTC HGF, defined as tumors with maintained nuclear features of PTC and mitoses numbering 5 or more per 10 contiguous high-power fields and/or tumor necrosis, and PDTC (defined as per the WHO criteria) were identified. Clinicopathologic characteristics, follow-up data, and targeted next-generation sequencing results were compared between groups.
Results: There were 15 PTC HGF and 47 PDTC. PTC HGF was associated with a higher rate of pT4 disease (53% vs. 13%, p = 0.0027) and lymph node metastases (73% vs. 38%, p …
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KS Wong, F Dong, M Telatar, JH Lorch, EK Alexander… - Thyroid, 2021