作者
Spyridon G Deftereos, Georgios Giannopoulos, Dimitrios A Vrachatis, Gerasimos D Siasos, Sotiria G Giotaki, Panagiotis Gargalianos, Simeon Metallidis, George Sianos, Stefanos Baltagiannis, Periklis Panagopoulos, Konstantinos Dolianitis, Efthalia Randou, Konstantinos Syrigos, Anastasia Kotanidou, Nikolaos G Koulouris, Haralampos Milionis, Nikolaos Sipsas, Charalampos Gogos, George Tsoukalas, Christoforos D Olympios, Eleftheria Tsagalou, Ilias Migdalis, Styliani Gerakari, Christos Angelidis, Dimitrios Alexopoulos, Pericles Davlouros, George Hahalis, Ioannis Kanonidis, Demosthenes Katritsis, Theofilos Kolettis, Antonios S Manolis, Lampros Michalis, Katerina K Naka, Vlasios N Pyrgakis, Konstantinos P Toutouzas, Filippos Triposkiadis, Konstantinos Tsioufis, Emmanouil Vavouranakis, Luis Martinèz-Dolz, Bernhard Reimers, Giulio G Stefanini, Michael Cleman, John Goudevenos, Sotirios Tsiodras, Dimitrios Tousoulis, Efstathios Iliodromitis, Roxana Mehran, George Dangas, Christodoulos Stefanadis
发表日期
2020/6/1
期刊
JAMA network open
卷号
3
期号
6
页码范围
e2013136-e2013136
出版商
American Medical Association
简介
Importance
Severe acute respiratory syndrome coronavirus 2 infection has evolved into a global pandemic. Low-dose colchicine combines anti-inflammatory action with a favorable safety profile.
Objective
To evaluate the effect of treatment with colchicine on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019 (COVID-19).
Design, Setting, and Participants
In this prospective, open-label, randomized clinical trial (the Greek Study in the Effects of Colchicine in COVID-19 Complications Prevention), 105 patients hospitalized with COVID-19 were randomized in a 1:1 allocation from April 3 to April 27, 2020, to either standard medical treatment or colchicine with standard medical treatment. The study took place in 16 tertiary hospitals in Greece.
Intervention
Colchicine administration (1.5-mg loading dose followed by 0.5 mg after 60 min and maintenance doses of 0 …
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SG Deftereos, G Giannopoulos, DA Vrachatis… - JAMA network open, 2020