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Since the description of catastrophizing by Ellis (Reason and emotion in psychotherapy. Lyle Stuart, Oxford, 1962) as a general factor in psychopathology, numerous studies have explored this construct and its association with many common disorders. This paper investigates the role of catastrophic thinking across psychiatric disorders. We conducted a comprehensive review of the literature on the role of catastrophic beliefs as a predictor and correlate of psychopathological disorders including panic, phobia, health anxiety, obsessive–compulsive disorder, posttraumatic stress disorder, pain, and traumatic brain injury. The literature suggests that catastrophic thinking has been demonstrated to play a role in a wide variety of disorders and has been a focal point for prevention and psychotherapeutic intervention. While the process of catastrophic thinking is transdiagnostic, content is unique for each disorder …