作者
Damon Wong, Jacqueline Chua, Mani Baskaran, Bingyao Tan, Xinwen Yao, Samuel Chan, Yih Chung Tham, Rachel Chong, Tin Aung, Ecosse Luc Lamoureux, Eranga N Vithana, Ching Yu Cheng, Leopold Schmetterer
发表日期
2021/3/1
期刊
British Journal of Ophthalmology
卷号
105
期号
3
页码范围
397-402
出版商
BMJ Publishing Group Ltd
简介
Background/aims
To identify factors that influence the diagnostic performance of circumpapillary retinal nerve fibre layer (RNFL) thickness measurements in the detection of primary open-angle glaucoma (POAG).
Methods
1592 eyes from 1076 healthy controls and 758 eyes from 502 patients with POAG underwent optical coherence tomography (OCT) imaging to assess RNFL parameters. Visual field (VF) mean deviation (MD) from standard automated perimetry was used to indicate severity in subjects with glaucoma.
Results
RNFL thickness significantly decreased with age (ρ=−0.10 to −0.16, p<0.001) and increased with spherical equivalent (SE) refractive error (ρ=0.23–0.29, p<0.001) in healthy and glaucoma groups but showed a significant reduction with SE (ρ=−0.20, p<0.001) in the temporal RNFL of healthy subjects. RNFL measurements significantly decreased with VF MD (ρ=0.08–0.53, p<0.05) in subjects …
学术搜索中的文章
D Wong, J Chua, M Baskaran, B Tan, X Yao, S Chan… - British Journal of Ophthalmology, 2021