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The purpose of the present study was to extend the research on the Psychology of Working Theory (PWT; Duffy, Blustein, Diemer, & Autin, 2016) by testing its applicability to workers with chronic health conditions. Specifically, we examined the PWT's posited predictors of securing decent work in a sample of 320 workers diagnosed with Chiari malformation-Type 1 (CM). Results of structural equation modeling analyses supported 8 of the 14 hypothesized relations. Notably, economic constraints and marginalization significantly and inversely predicted decent work and work volition; economic constraints significantly and inversely predicted career adaptability, which in turn significantly and positively predicted decent work; and career adaptability partially explained the significant relation of economic constraints to decent work. Collectively, our findings provided strong support for the applicability of the PWT for workers …