作者
Mohamed Mansor Manan, Nazedah Ain Ibrahim, Noorizan Abd Aziz, Hanis Hanum Zulkifly, Yaser Mohammed Ali Al-Worafi, Chiau Ming Long
发表日期
2016/6/1
期刊
Archives of Medical Science
卷号
12
期号
3
页码范围
603-613
出版商
Termedia
简介
Results: Three hundred and twenty-three cases met the inclusion criteria and were divided into gestational age (premature< 36 weeks; term≥ 37 weeks) and birth weight (low birth weight (LBW)< 2.5 kg; normal body weight (NBW)≥ 2.5 kg) groups. Premature (n= 197) and LBW (n= 194) neonates required significantly longer hospital stay, a higher degree of ventilator support and more surfactant (p= 0.001). More than 90.0% of premature and LBW neonates were diagnosed with respiratory distress syndrome, congenital pneumonia and presumed sepsis. Term (n= 123) and NBW (n= 129) neonates had greater maternal risk factors, especially meconium-stained amniotic fluid (MSAF) and perinatal asphyxia. The incidence of demonstrated EOS was 3.1%. Crystalline penicillin plus gentamicin was the standard therapy for all groups and was started within 24 h of life, with a mean treatment duration of~ 4 days. The treatment success rate was 89.0%, and only LBW neonates showed a higher risk of overall treatment failure (OR= 3.75; 95% CI: 1.22–11.53). Seventy-four percent of term and NBW neonates discharged well, while 42.0% of premature and LBW neonates required referral.
Conclusions: Crystalline penicillin plus gentamicin prescribed within 24 h of life is effective in the prevention of EOS. However, low birth weight neonates have a higher risk of treatment failure.
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