作者
Ruiyi Tian, Brian Wiley, Jie Liu, Xiaoyu Zong, Buu Truong, Stephanie Zhao, Md Mesbah Uddin, Abhishek Niroula, Christopher A Miller, Semanti Mukherjee, Brendan T Heiden, Jingqin Luo, Varun Puri, Benjamin D Kozower, Matthew J Walter, Li Ding, Daniel C Link, Christopher I Amos, Benjamin L Ebert, Ramaswamy Govindan, Pradeep Natarajan, Kelly L Bolton, Yin Cao
发表日期
2023/3/1
期刊
Journal of Clinical Oncology
卷号
41
期号
7
页码范围
1423-1433
出版商
Wolters Kluwer Health
简介
PURPOSE
To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer.
METHODS
Among 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nested case-control study (141 cases/652 controls) was conducted among 27,975 participants with whole-exome sequencing in the Mass General Brigham Biobank (MGBB, 2010-2021). In parallel, we compared CH frequency in published data from 5,003 patients with solid tumor (2,279 lung cancer) who had pretreatment blood sequencing performed through Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets.
RESULTS
In UKBB, the presence of CH was associated with …
学术搜索中的文章
R Tian, B Wiley, J Liu, X Zong, B Truong, S Zhao… - Journal of Clinical Oncology, 2023