作者
Bianca Weinstock-Guttman, Robert Zivadinov, Naeem Mahfooz, Ellen Carl, Allison Drake, Jaclyn Schneider, Barbara Teter, Sara Hussein, Bijal Mehta, Marc Weiskopf, Jacqueline Durfee, Niels Bergsland, Murali Ramanathan
发表日期
2011/12
期刊
Journal of neuroinflammation
卷号
8
页码范围
1-7
出版商
BioMed Central
简介
Background
The breakdown of the blood-brain-barrier vascular endothelium is critical for entry of immune cells into the MS brain. Vascular co-morbidities are associated with increased risk of progression. Dyslipidemia, elevated LDL and reduced HDL may increase progression by activating inflammatory processes at the vascular endothelium.
Objective
To assess the associations of serum lipid profile variables (triglycerides, high and low density lipoproteins (HDL, LDL) and total cholesterol) with disability and MRI measures in multiple sclerosis (MS).
Methods
This study included 492 MS patients (age: 47.1 ± 10.8 years; disease duration: 12.8 ± 10.1 years) with baseline and follow-up Expanded Disability Status Score (EDSS) assessments after a mean period of 2.2 ± 1.0 years. The associations of baseline lipid profile …
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B Weinstock-Guttman, R Zivadinov, N Mahfooz, E Carl… - Journal of neuroinflammation, 2011