作者
Ralph HB Benedict, Elizabeth Wahlig, Rohit Bakshi, Inna Fishman, Frederick Munschauer, Robert Zivadinov, Bianca Weinstock-Guttman
发表日期
2005/4/15
期刊
Journal of the neurological sciences
卷号
231
期号
1-2
页码范围
29-34
出版商
Elsevier
简介
Health-related quality of life (HQOL) is poor in multiple sclerosis (MS) but the clinical precipitants of the problem are not well understood. Previous correlative studies demonstrated relationships between various clinical parameters and diminished HQOL in MS. Unfortunately, these studies failed to account for multiple predictors in the same analysis. We endeavored to determine what clinical parameters account for most variance in predicting HQOL, and employability, while accounting for disease course, physical disability, fatigue, cognition, mood disorder, personality, and behavior disorder. In 120 MS patients, we measured HQOL (MS Quality of Life-54) and vocational status (employed vs. disabled) and then conducted detailed clinical testing. Data were analyzed by linear and logistic regression methods. MS patients reported lower HQOL (p<0.001) and were more likely to be disabled (45% of patients vs. 0 …
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