作者
Ralph HB Benedict, Jared M Bruce, Michael G Dwyer, Nadir Abdelrahman, Sarah Hussein, Bianca Weinstock-Guttman, Neeta Garg, Frederick Munschauer, Robert Zivadinov
发表日期
2006/9/1
期刊
Archives of neurology
卷号
63
期号
9
页码范围
1301-1306
出版商
American Medical Association
简介
Background
Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results.
Objective
To determine if neocortical volume would supplant or supplement third ventricular width and other magnetic resonance imaging measures when predicting neuropsychological impairment.
Design
Cross-sectional study.
Setting
University MS clinic.
Participants
Seventy-seven patients with relapsing-remitting MS, 42 patients with secondary progressive MS, and 27 healthy control subjects.
Main Outcome Measures
Brain atrophy and lesion burden measures were obtained in all patients. A subset of 82 patients and all controls underwent neuropsychological testing.
Results
Patients with secondary progressive MS had more atrophy than patients with relapsing-remitting MS and controls. Neocortical volume was significantly correlated with all neuropsychological …
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