作者
Pascal Sati, Jiwon Oh, R Todd Constable, Nikos Evangelou, Charles RG Guttmann, Roland G Henry, Eric C Klawiter, Caterina Mainero, Luca Massacesi, Henry McFarland, Flavia Nelson, Daniel Ontaneda, Alexander Rauscher, William D Rooney, Amal PR Samaraweera, Russell T Shinohara, Raymond A Sobel, Andrew J Solomon, Constantina A Treaba, Jens Wuerfel, Robert Zivadinov, Nancy L Sicotte, Daniel Pelletier, Daniel S Reich
发表日期
2016/12
来源
Nature Reviews Neurology
卷号
12
期号
12
页码范围
714-722
出版商
Nature Publishing Group
简介
Over the past few years, MRI has become an indispensable tool for diagnosing multiple sclerosis (MS). However, the current MRI criteria for MS diagnosis have imperfect sensitivity and specificity. The central vein sign (CVS) has recently been proposed as a novel MRI biomarker to improve the accuracy and speed of MS diagnosis. Evidence indicates that the presence of the CVS in individual lesions can accurately differentiate MS from other diseases that mimic this condition. However, the predictive value of the CVS for the development of clinical MS in patients with suspected demyelinating disease is still unknown. Moreover, the lack of standardization for the definition and imaging of the CVS currently limits its clinical implementation and validation. On the basis of a thorough review of the existing literature on the CVS and the consensus opinion of the members of the North American Imaging in Multiple Sclerosis …
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P Sati, J Oh, RT Constable, N Evangelou… - Nature Reviews Neurology, 2016