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Adenosine receptors are involved in interactions with receptors for other neurotransmitters and/or neuromodulators. This opens novel possibilities for the action of this nucleoside. Either through direct receptor–receptor modulation or beyond the receptor level (PKA, PKC, or calcium channels), it appears that to protect the cells from insult adenosine moves around to use as many several receptor systems as possible, namely, receptors for neuropeptides (CGRP and VIP), ionotropic (NMDA) and metabotropic (mGlur I and III) glutamate receptors, GABA, and nicotinic autofacilitatory, muscarinic, and dopamine receptors. With these, adenosine might synchronize or desynchronize synaptic transmission in order to fine‐tune the nervous system. Drug Dev. Res. 52:337–345, 2001. © 2001 Wiley‐Liss, Inc.