作者
Theresa Reiter, Malte Kircher, Andreas Schirbel, Rudolf A Werner, Saskia Kropf, Georg Ertl, Andreas K Buck, Hans-Jürgen Wester, Wolfgang R Bauer, Constantin Lapa
发表日期
2018/10
期刊
JACC: Cardiovascular Imaging
卷号
11
期号
10
页码范围
1541-1543
出版商
American College of Cardiology Foundation
简介
CXC motif chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1a have been shown to be involved in the orchestration of postinfarct inflammation and its resolution in patients with acute myocardial infarction (AMI)(1). Recently, pilot visualization of CXCR4-expression using a radiolabeled PET ligand ([68Ga] Pentixafor) could be demonstrated in patients after AMI (2, 3). The aim of this study was to further investigate CXCR4 expression after myocardial ischemia in comparison to cardiac magnetic resonance (CMR). From January 2015 to June 2016, 22 patients (17 men and 5 women, mean age 61 Æ 11 years) with (sub) acute myocardial infarction underwent imaging with [68Ga] Pentixafor-positron emission tomography (PET)/computed tomography (CT) and CMR (21 patients, 1 patient excluded because of adipositas permagna) within 2 to 13 days after onset of symptoms (median delay …
引用总数
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