作者
Malte Kircher, Peter Herhaus, Margret Schottelius, Andreas K Buck, Rudolf A Werner, Hans-Jürgen Wester, Ulrich Keller, Constantin Lapa
发表日期
2018/10
来源
Annals of nuclear medicine
卷号
32
页码范围
503-511
出版商
Springer Japan
简介
Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Additionally, CXCR4-directed endoradiotherapy (ERT) as a new treatment option is discussed.
学术搜索中的文章
M Kircher, P Herhaus, M Schottelius, AK Buck… - Annals of nuclear medicine, 2018