作者
Olivia Kertels, Milena I Mihovilovic, Thomas Linsenmann, Almuth F Kessler, Johannes Tran-Gia, Malte Kircher, Joachim Brumberg, Camelia Maria Monoranu, Samuel Samnick, Ralf-Ingo Ernestus, Mario Löhr, Philipp T Meyer, Constantin Lapa
发表日期
2019/9/1
期刊
Clinical Nuclear Medicine
卷号
44
期号
9
页码范围
695-701
出版商
LWW
简介
Purpose
PET/CT using O-(2-[18 F] fluoroethyl)-l-tyrosine (18 F-FET) has proven valuable in differentiating tumor recurrence and progression from therapy-induced changes. This study aimed to investigate the diagnostic performance of several analytic approaches in the setting of suspected late pseudoprogression (PsP) in glioblastoma multiforme (GBM).
Methods
Retrospective analysis of tumor recurrence was performed in 36 patients with histopathologically confirmed GBM and suspicion of recurrence/disease progression more than 12 weeks from cessation of irradiation based on MRI and Response Assessment in Neuro-Oncology working group criteria. For differentiation of late PsP from true tumor recurrence, images were analyzed semiquantitatively employing tumor-to-brain ratios using 5 different approaches for tumor and normal brain reference region definition, respectively. Histopathology and/or clinical and …
学术搜索中的文章
O Kertels, MI Mihovilovic, T Linsenmann, AF Kessler… - Clinical Nuclear Medicine, 2019