作者
Christian Linz, Roman C Brands, Olivia Kertels, Alexander Dierks, Joachim Brumberg, Elena Gerhard-Hartmann, Stefan Hartmann, Andreas Schirbel, Sebastian Serfling, Yingjun Zhi, Andreas K Buck, Alexander Kübler, Julian Hohm, Constantin Lapa, Malte Kircher
发表日期
2021/11
期刊
European journal of nuclear medicine and molecular imaging
卷号
48
期号
12
页码范围
3951-3960
出版商
Springer Berlin Heidelberg
简介
Purpose
While [18F]-fluorodeoxyglucose ([18F]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous cell carcinoma (OSCC), diagnostic specificity is hampered by uptake in inflammatory cells such as neutrophils or macrophages. Recently, molecular imaging probes targeting fibroblast activation protein α (FAP), which is overexpressed in a variety of cancer-associated fibroblasts, have become available and might constitute a feasible alternative to FDG PET/CT.
Methods
Ten consecutive, treatment-naïve patients (8 males, 2 females; mean age, 62 ± 9 years) with biopsy-proven OSCC underwent both whole-body [18F]FDG and [68Ga]FAPI-04 (FAP-directed) PET/CT for primary staging prior to tumor resection and cervical lymph node dissection. Detection of the primary tumor, as well as the presence and number of lymph node and distant metastases was …
学术搜索中的文章
C Linz, RC Brands, O Kertels, A Dierks, J Brumberg… - European journal of nuclear medicine and molecular …, 2021