作者
Malte Kircher, Sandra Ihne, Joachim Brumberg, Caroline Morbach, Stefan Knop, K Martin Kortüm, Stefan Störk, Andreas K Buck, Theresa Reiter, Wolfgang R Bauer, Constantin Lapa
发表日期
2019/7/1
期刊
European journal of nuclear medicine and molecular imaging
卷号
46
页码范围
1407-1416
出版商
Springer Berlin Heidelberg
简介
Purpose
Cardiac amyloidosis (CA) is a rare cause of heart failure with frequently delayed diagnosis, because specific early signs or symptoms are missing. Recently, direct amyloid imaging using positron emission tomography/computed tomography (PET/CT) has emerged.
The aim of this study was to examine the performance of 18F-florbetaben-PET/CT in detection of CA, and compare it to echocardiography (echo), cardiac MRI (CMR) and scintigraphy. Additionally, the use of 18F-florbetaben-PET/CT for quantification of amyloid burden and monitoring of treatment response was assessed.
Methods
Twenty-two patients with proven (n = 5) or clinical suspicion (n = 17) of CA underwent 18F-florbetaben-PET/CT for diagnostic work-up. Qualitative and quantitative assessment including calculation of myocardial tracer retention (MTR) was …
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M Kircher, S Ihne, J Brumberg, C Morbach, S Knop… - European journal of nuclear medicine and molecular …, 2019