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Two‐dimensional (2D) breath‐hold cine MRI is used to assess cardiac anatomy and function. However, this technique requires cooperation from the patient, and in some cases the scan planning is complicated. Isotropic nonangulated three‐dimensional (3D) cardiac MR can overcome some of these problems because it requires minimal planning and can be reformatted in any plane. However, current methods, even those that use undersampling techniques, involve breath‐holding for periods that are too long for many patients. Free‐breathing respiratory gating sequences represent a possible solution for realizing 3D cine imaging. A real‐time respiratory self‐gating technique for whole‐heart cine MRI is presented. The technique enables assessment of cardiac anatomy and function with minimum planning or patient cooperation. Nonangulated isotropic 3D data were acquired from five healthy volunteers and then …