作者
Elena Valassi, Richard Feelders, Dominique Maiter, Philippe Chanson, Maria Yaneva, Martin Reincke, Michal Krsek, Miklós Tóth, Susan M Webb, Alicia Santos, Isabel Paiva, Irina Komerdus, Michael Droste, Antoine Tabarin, Christian J Strasburger, Holger Franz, Peter J Trainer, John Newell‐Price, John AH Wass, Eleni Papakokkinou, Oskar Ragnarsson, ERCUSYN Study Group, A Ambrogio, G Aranda, M Arosio, M Balomenaki, P Beck‐Peccoz, C Berr‐Kirmair, M Bolanowski, J Bollerslev, B Thierry, D Carvalho, F Cavagnini, E Christ, F Demtröder, J Denes, C Dimopoulou, A Dreval, T Dusek, E Erdinc, JA Evang, J Fazel, S Fica, E Ghigo, M Goth, Y Greenman, V Greisa, I Halperin, FA Hanzu, A Hermus, G Johannsson, P Kamenicky, A Kasperlik‐Zaluska, J Kirchner, K Darko, I Kraljevic, A Kruszynska, I Lambrescu, S Lang, A Luger, N Marpole, S Martin, M Martinie, O Moros, M Orbetzova, F Pecori Giraldi, AM Pereira, J Pickel, V Pirags, AD Reghina, M Roberts, S Roerink, O Roig, C Rowan, P Rudenko, MA Sahnoun, J Salvador, HA Sigurjonsdottir, T Skoric Polovina, R Smith, B Stachowska, G Stalla, J Tőke, E Ubina, S Vinay, M Wagenmakers, S Werner, J Young, P Zdunowski, K Zopf, S Zopp, I Zosin
发表日期
2018/6
期刊
Clinical endocrinology
卷号
88
期号
6
页码范围
787-798
简介
Objective
Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health‐related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT‐CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR‐CS).
Methods
Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ‐5D questionnaires at baseline and/or following treatment were analysed.
Results
At baseline, HRQoL did not differ between PIT‐CS (n = 293) and ADR‐CS (n = 120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT‐CS and ADR‐CS was 41 ± 18 and 44 ± 20, respectively (P = .7). At long‐time follow‐up (>1 year after treatment) total CushingQoL score was however lower in PIT‐CS than ADR‐CS …
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E Valassi, R Feelders, D Maiter, P Chanson, M Yaneva… - Clinical endocrinology, 2018