作者
Edouard I Azzam, Jean-Paul Jay-Gerin, Debkumar Pain
发表日期
2012/12/31
期刊
Cancer letters
卷号
327
期号
1
页码范围
48-60
出版商
Elsevier
简介
Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure through direct interactions of radiation with target macromolecules or via products of water radiolysis. Further, the oxidative damage may spread from the targeted to neighboring, non-targeted bystander cells through redox-modulated intercellular communication mechanisms. To cope with the induced stress and the changes in the redox environment, organisms elicit transient responses at the molecular, cellular and tissue levels to counteract toxic effects of radiation. Metabolic pathways are induced during and shortly after the exposure. Depending on radiation dose, dose-rate and quality, these protective mechanisms may or may not be sufficient to cope with the stress. When the harmful effects exceed those of homeostatic biochemical processes, induced biological changes persist and may be propagated to progeny cells …
学术搜索中的文章
EI Azzam, JP Jay-Gerin, D Pain - Cancer letters, 2012