作者
Fariba Karimzadeh, Mahmoud Hosseini, Diana Mangeng, Hassan Alavi, Gholam Reza Hassanzadeh, Mohamad Bayat, Maryam Jafarian, Hadi Kazemi, Ali Gorji
发表日期
2012/12
期刊
BMC complementary and alternative medicine
卷号
12
页码范围
1-9
出版商
BioMed Central
简介
Background
Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil.
Methods
The effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain.
Results
Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil …
学术搜索中的文章
F Karimzadeh, M Hosseini, D Mangeng, H Alavi… - BMC complementary and alternative medicine, 2012