作者
Kimberly R Byrnes, David J Loane, Bogdan A Stoica, Jiangyang Zhang, Alan I Faden
发表日期
2012/12
期刊
Journal of neuroinflammation
卷号
9
页码范围
1-15
出版商
BioMed Central
简介
Background
Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in association with chronic microglial activation. Recently we found that metabotropic glutamate receptor 5 (mGluR5) activation by (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) decreases microglial activation and release of associated pro-inflammatory factors in vitro, which is mediated in part through inhibition of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Here we examined whether delayed CHPG administration reduces chronic neuroinflammation and associated neurodegeneration after experimental traumatic brain injury in mice.
Methods
One month after controlled cortical impact traumatic brain injury, C57Bl …
学术搜索中的文章
KR Byrnes, DJ Loane, BA Stoica, J Zhang, AI Faden - Journal of neuroinflammation, 2012