作者
Kimberly R Byrnes, Ronald W Waynant, Ilko K Ilev, Xingjia Wu, Lauren Barna, Kimberly Smith, Reed Heckert, Heather Gerst, Juanita J Anders
发表日期
2005/3
期刊
Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery
卷号
36
期号
3
页码范围
171-185
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Background and Objectives
Photobiomodulation (PBM) has been proposed as a potential therapy for spinal cord injury (SCI). We aimed to demonstrate that 810 nm light can penetrate deep into the body and promote neuronal regeneration and functional recovery.
Study Design/Materials and Methods
Adult rats underwent a T9 dorsal hemisection, followed by treatment with an 810 nm, 150 mW diode laser (dosage = 1,589 J/cm2). Axonal regeneration and functional recovery were assessed using single and double label tract tracing and various locomotor tasks. The immune response within the spinal cord was also assessed.
Results
PBM, with 6% power penetration to the spinal cord depth, significantly increased axonal number and distance of regrowth (P < 0.001). PBM also returned aspects of function to baseline levels and significantly suppressed immune cell activation and cytokine/chemokine …
引用总数
学术搜索中的文章
KR Byrnes, RW Waynant, IK Ilev, X Wu, L Barna… - Lasers in Surgery and Medicine: The Official Journal of …, 2005