作者
Catherine R Mikus, Leryn J Boyle, Sarah J Borengasser, Douglas J Oberlin, Scott P Naples, Justin Fletcher, Grace M Meers, Meghan Ruebel, M Harold Laughlin, Kevin C Dellsperger, Paul J Fadel, John P Thyfault
发表日期
2013/8/20
期刊
Journal of the American College of Cardiology
卷号
62
期号
8
页码范围
709-714
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to determine if simvastatin impairs exercise training adaptations.
Background
Statins are commonly prescribed in combination with therapeutic lifestyle changes, including exercise, to reduce cardiovascular disease risk in patients with metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired mitochondrial function, but it is unclear whether statin use alters adaptations to exercise training.
Methods
This study examined the effects of simvastatin on changes in cardiorespiratory fitness and skeletal muscle mitochondrial content in response to aerobic exercise training. Sedentary overweight or obese adults with at least 2 metabolic syndrome risk factors (defined according to National Cholesterol Education Panel Adult Treatment Panel III criteria) were randomized to 12 weeks of aerobic exercise training or to exercise in combination with simvastatin (40 mg/day …
学术搜索中的文章
CR Mikus, LJ Boyle, SJ Borengasser, DJ Oberlin… - Journal of the American College of Cardiology, 2013