作者
Rodolfo G Gatto, Allen Q Ye, Luis Colon-Perez, Thomas H Mareci, Anna Lysakowski, Steven D Price, Scott T Brady, Muge Karaman, Gerardo Morfini, Richard L Magin
发表日期
2019/8/1
期刊
Magnetic Resonance Materials in Physics, Biology and Medicine
卷号
32
页码范围
461-471
出版商
Springer International Publishing
简介
Objective
The goal of this work is to study the changes in white matter integrity in R6/2, a well-established animal model of Huntington’s disease (HD) that are captured by ex vivo diffusion imaging (DTI) using a high field MRI (17.6 T).
Materials and methods
DTI and continuous time random walk (CTRW) models were used to fit changes in the diffusion-weighted signal intensity in the corpus callosum of controls and in R6/2 mice.
Results
A significant 13% decrease in fractional anisotropy, a 7% increase in axial diffusion, and a 33% increase in radial diffusion were observed between R6/2 and control mice. No change was observed in the CTRW beta parameter, but a significant decrease in the alpha parameter (− 21%) was measured. Histological analysis of the corpus callosum showed a decrease in axonal organization …
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RG Gatto, AQ Ye, L Colon-Perez, TH Mareci… - Magnetic Resonance Materials in Physics, Biology and …, 2019