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ABSTRACTBackground: Fat myringoplasty had been described over 50 years to be a safe and simple option formyringoplasty. Platelet rich plasma [PRP] is a simple and minimally invasive method to obtain a highconcentrate of autologous growth factors that can facilitate wound healing.

To assess the effectiveness of using fat and PRP in myringoplasty.

Twenty patients with small to medium sized tympanic membrane perforations wereenrolled in this study. Under local anesthesia, the margin of the perforation was freshened, then a singlepiece of ear lobule fat graft, approximately double the size of the perforation, was placed through theperforation, then the PRP was applied over the fat graft.

Successful TM perforation repair was achieved in 36 ears [85.7%]. 100% success rate wasobtained in small peroration and 79.3%in medium sized perforation. There was significant postoperativeimprovement in the mean air bone gap [p = 0.0016].

Adding PRP to fat myringoplasty is a safe, effective, cost saving and minimally invasiveprocedure. It is suitable to repair small as well as moderate sized TM perforations.