作者
Li Shen, Pardeep S Jhund, Mark C Petrie, Brian L Claggett, Simona Barlera, John GF Cleland, Henry J Dargie, Christopher B Granger, John Kjekshus, Lars Køber, Roberto Latini, Aldo P Maggioni, Milton Packer, Bertram Pitt, Scott D Solomon, Karl Swedberg, Luigi Tavazzi, John Wikstrand, Faiez Zannad, Michael R Zile, John JV McMurray
发表日期
2017/7/6
期刊
New England Journal of Medicine
卷号
377
期号
1
页码范围
41-51
出版商
Massachusetts Medical Society
简介
Background
The risk of sudden death has changed over time among patients with symptomatic heart failure and reduced ejection fraction with the sequential introduction of medications including angiotensin-converting–enzyme inhibitors, angiotensin-receptor blockers, beta-blockers, and mineralocorticoid-receptor antagonists. We sought to examine this trend in detail.
Methods
We analyzed data from 40,195 patients who had heart failure with reduced ejection fraction and were enrolled in any of 12 clinical trials spanning the period from 1995 through 2014. Patients who had an implantable cardioverter–defibrillator at the time of trial enrollment were excluded. Weighted multivariable regression was used to examine trends in rates of sudden death over time. Adjusted hazard ratios for sudden death in each trial group were calculated with the use of Cox regression models. The cumulative incidence rates of sudden …
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L Shen, PS Jhund, MC Petrie, BL Claggett, S Barlera… - New England Journal of Medicine, 2017