作者
Krista F Huybrechts, Gabriella Bröms, Lotte Brix Christensen, Kristjana Einarsdóttir, Anders Engeland, Kari Furu, Mika Gissler, Sonia Hernandez-Diaz, Pär Karlsson, Øystein Karlstad, Helle Kieler, Anna-Maria Lahesmaa-Korpinen, Helen Mogun, Mette Nørgaard, Johan Reutfors, Henrik Toft Sørensen, Helga Zoega, Brian T Bateman
发表日期
2018/2/1
期刊
JAMA psychiatry
卷号
75
期号
2
页码范围
167-175
出版商
American Medical Association
简介
Importance
Given the rapidly increasing use of stimulant medications during pregnancy and among women of reproductive age who may become pregnant inadvertently, there is a need to better understand their safety.
Objective
To examine the risk of congenital malformations associated with intrauterine exposure to stimulants.
Design, Setting, and Participants
Cohort study of the Medicaid-insured population in the United States nested in the 2000-2013 US Medicaid Analytic eXtract, with follow-up of safety signals detected in the Medicaid Analytic eXtract data using the Nordic Health registries (2003-2013) (Denmark, Finland, Iceland, Norway, and Sweden). A total of 1 813 894 publicly insured pregnancies in the United States and 2 560 069 singleton pregnancies in the 5 Nordic countries ending in live births were included. Relative risks were estimated accounting for underlying psychiatric disorders and other …
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KF Huybrechts, G Bröms, LB Christensen… - JAMA psychiatry, 2018