作者
Gabriella Bröms, Helle Kieler, Anders Ekbom, Mika Gissler, Karin Hellgren, Maarit K Leinonen, Lars Pedersen, Marcus Schmitt‐Egenolf, Henrik Toft Sørensen, Fredrik Granath
发表日期
2020/9
期刊
Alimentary Pharmacology & Therapeutics
卷号
52
期号
5
页码范围
843-854
简介
Background
Most anti‐tumour necrosis factor (anti‐TNF) agents are transferred across the placenta and may increase paediatric susceptibility to infections.
Aims
To assess the risk of paediatric infections after maternal anti‐TNF treatment.
Methods
Population‐based cohort study in Denmark, Finland and Sweden 2006‐2013 in which 1027 children born to women with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis or inflammatory bowel disease, treated with anti‐TNF, and 9346 children to women with non‐biologic systemic treatment, were compared to 1 617 886 children of the general population. Children were followed for 3 years.
Results
Adjusted by maternal age, parity, smoking, body mass index, country and calendar year, the incidence rate ratios with 95% confidence interval (CI) for hospital admissions for infection in the first year were 1.43 (1.23‐1.67) for anti‐TNF and 1.14 (1.07 …
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G Bröms, H Kieler, A Ekbom, M Gissler, K Hellgren… - Alimentary Pharmacology & Therapeutics, 2020