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The present study was considered to assess the antihypertensive and antioxidant effect of valproic acid, against Nω- nitro-L arginine methyl ester hydrochloride (L-NAME) induced hypertension in male Wistar rats. Hypertension was prompted in adult male albino rats of the Wistar strain, weighing 180–220 g, by oral administration of the L-NAME (40 mg/kg body weight/day) in drinking water for 4 weeks. The L- NAME hypertensive rats revealed significant (P < 0.05) rise in the systolic and diastolic blood pressure, heart rate, water intake and heart weight L-NAME hypertensive rats also revealed significant (P < 0.05) increase in the levels of thiobarbituric acid reactive substances, lipid hydroperoxides in plasma and tissues (heart and aorta), and significant (P < 0.05) drop in the body weight, nitrite and nitrate levels in plasma and aorta. Activities of enzymic antioxidants such as superoxide dismutase, catalase and …