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Inhibition of programmed cell death (apoptosis) is associated with increased tumour aggressiveness, and expression ofSurvivin, an antiapoptosis gene, in colorectal carcinomas may provide important prognostic information.

Expression of Survivin messenger RNA was evaluated by reverse transcription-polymerase chain reaction in 144 colorectal carcinomas and 86 adjacent histologically normal mucosa samples from patients for whom long term follow up data were available.

Survivintranscripts were detected in a significantly greater proportion of carcinomas (63.5%) than normal mucosa samples (29.1%; p<0.001). The prevalence of Survivin expression was independent of advancing pathological stage. Death due to recurrent cancer following curative resection was predicted independently by tumour expression of Survivin (hazard ratio (HR) 2.60; 95 …